The short answer is no. The reason being is because when we inject fillers, we inject to different layers of the skin and it penetrates further.
But for topical creams with hyaluronic acid properties, I would say there are 2 factors that will determine how well it absorbs. Obviously it will be less wild compared to the injection but it does not mean it does not work.
Firstly, let's say number one would be the driver, which stand for the specific molecules in the product that helps to drive the hyaluronic acid into the deeper layer of the skin.
Secondly, depending on the molecules of the hyaluronic acid, low molecule or high molecule, that will again affect how deep our skin absorbs it. So, I won't say it can be substituted but I think it can work as an adjunct to fillers.
