Treatment of Acanthamoeba keratitis is difficult, even in post-Lasik patients. This is due to the resilient nature of the cyst form. Current treatment regimens usually include a topical cationic antiseptic agent such as polyhexamethylene biguanide (0.02%) or chlorhexidine (0.02%) with or without a diamidine such as propamidine (0.1%) or hexamidine (0.1%).
In severe cases of infection, therapeutic corneal transplantation to reduce the pathogen load may even be required.